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2 Direct impact of sulfonylureas on ion channels besides K ATP channels 2.1 K + channels The repolarization of glucose-induced action potential (AP) in pancreatic -cells is attributed to K + efflux via several K + channels such as Kv channels, the process of which governs the duration of AP and subsequent Ca 2+ influx crucial for secreting insulin

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Barassi A, Pezzilli R, Colpi GM, Corsi Romanelli MM, Melzid Eril GV

The cag + tirz combination covers three pathways instead of two, but it has no human trial data of its own