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Survodutide (Boehringer Ingelheim, Phase 3 SYNCHRONIZE) and mazdutide (Innovent, approved in China, filed ex-China) both sit in the ~14-18% placebo-adjusted range at their highest-dose arms - comfortably above semaglutide, comfortably below the triples
Many contain stimulants such as caffeine or synephrine, which can increase heart rate and blood pressureeffects that may be additive with fluoxetine in some individuals, leading to palpitations or cardiovascular strain
This is speculation based on the broader GLP-1 nasal delivery literature, not confirmed data for retatrutide specifically
Between uses, the vial septum should be protected from contamination, and proper aseptic technique should be used for each withdrawal
10.1126/science.1123511 45 BonfiliL.CecariniV.GogoiO.BerardiS.ScarponaS.AngelettiM.et al
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