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ACKNOWLEDGEMENTS The authors acknowledge the technical assistance provided by Ruth Pfeiffer

Strategies to combat antibiotic resistance using nano-delivery systems Bacterial multidrug efflux pumps are the major contributors to antibiotic resistance formation in microbial pathogens

Subjects consumed two sachets daily one morning, one early afternoon preferably on an empty stomach

Glutathione neutralizes reactive compounds, protects cells from oxidative stress, and facilitates the excretion of toxins by forming water-soluble conjugates

Additionally, the antioxidant enzymes glutathione reductase, catalase, GPx, and SOD can be employed to monitor and correct the activity of these enzymes both before and during medication [217]