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During the DPP study, metformin reduced the risk of overt DM by 31% when compared with the placebo.53 In a secondary analysis of the DPP study with 10-year of follow-up, the authors showed a reduction in the onset risk of DM by 18%, demonstrating a sustained long-term benefit.62 In addition, in animal models of kidney injury, metformin has demonstrated renoprotective effects in terms of decreasing inflammation, apoptosis, reactive oxygen stress, endoplasmic reticulum stress, epithelialmesenchymal transition via AMPK activation.29 Nephroprotective effects of metformin

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Mood stabilization represents another potential benefit