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The detailed regulation of PFK1 in TC has not been illustrated yet, but the increase of this enzyme regulating the first committed step of glycolytic pathway is clear [74, 75]

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Microglia, central players in neuroinflammation, can transform into a phagocytic state and remodel neuronal connectivity, damaging the BBB by engulfing astrocyte endfeet AQP4 when peripheral inflammation breaches microvessels (89)

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Polyphenols are widely available in pomegranate extract