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Adverse Events: While generally well-tolerated, GLP-1 RAs are associated with gastrointestinal side effects, and rare but serious events like pancreatitis and thyroid C-cell tumors (observed in rodents) require ongoing monitoring

Density of the linker (K130 ECD S136 ECD ) and ICL3 (L399 ICL3 T343 ICL3 ) was not clear and these residues were omitted from the final model

This dualhormone combination can improve satiety and energy use more effectively than GLP1 alone

Prescription costs are always on the rise, so it is unlikely this price drop will ever happen

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