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Combined findings revealed that the risk of depression was linked to the utilization of GLP-1RA (OR = 1.49, 95% CI: 1.181.88)

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Retatrutide (LY3437943) is a novel triple agonist peptide targeting the GCGR, GIPR, and GLP-1R

In a Phase II trial, patients in the Mazdutide group saw a weight decrease between 5% and 22.5%, with a notable proportion of patients across different dosage groups achieving at least a 10% or even higher degree of weight reduction

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