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Furthermore, progressive loss of NRF2 activity was seen with aging, which may be explained by studies showing that the expression of NRF2 positive regulators P62 and BRCA1 decreased with age, while NRF2 negative regulators, KEAP1 and BACH1, increased with age [113]

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doi: 10.1016/j.freeradbiomed.2022.09.024 122 PellicoroARamachandranPIredaleJPFallowfieldJA