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UGT1A6 and UGT1A9 are the main UGT isoforms responsible for acetaminophen glucuronidation in humans (Figure 1, see Pharmacokinetics : Metabolism )

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A binomial logistic model was fitted to age, sex, and inclusion date using treatment group as the dependent variable ( We matched subjects 1:1 on the logit transformation of the propensity score by nearest-neighbor (greedy) matching without replacement, using a caliper width equal to 0.2 x the (pooled) SD of the transformed propensity scores ( For multiple imputed datasets, matching and statistical analyses were performed separately on each resultant dataset, and the statistical estimates were finally pooled

A significant reduction in pro-inflammatory molecules, including C-reactive protein (CRP), TNF- , and IL-6, was observed, indicating the inhibition of inflammatory pathways, likely at the level of immune system cells and adipocytes signaling

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