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In vitro evidence demonstrated that propionate upregulated gluconeogenic rate-limiting enzymesincluding phosphoenolpyruvate carboxykinase 2 (PEPCK2) and fructose-1,6-bisphosphatase 1 (FBP1)within jejunal epithelial cells, thereby supporting local mucosal energetics 74

The gdh3 / gdh3 mutant, however, showed a 24% reduction in its growth rate (0.302 h 1 ) compared to wild-type cells

Funding Statement This work received no specific funding

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