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employed ALD modeling of mice with fibronectin type III domain-containing 3B (FNDC3B) gene knockout and discovered that the absence of FNDC3B significantly exacerbated lipid peroxidation (You et al., 2022)

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The glucagon arm is the third lever: rather than only reducing energy intake through appetite, glucagon agonism raises energy expenditure and pushes the liver to mobilize stored fat