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Glutamine depletion impairs cellular stress response in human leucocytes

Given semaglutides effects on dopaminergic signalling [38] we were surprised to find no difference in effort-based decision-making between participants on or off semaglutide

- Semaglutide led to a significant reduction in HbA1c levels compared to placebo- Patients receiving semaglutide experienced significant weight loss compared to those on placebo PIONEER Trials (Peptide Innovation for Early Diabetes Treatment): The PIONEER (Peptide Innovation for Early Diabetes Treatment) trials were a series of global, randomized, controlled clinical trials that investigated the efficacy, safety, and tolerability of oral semaglutide, a GLP-1 receptor agonist, in patients with type 2 diabetes

doi: 10.1105/tpc.106.044230 106 MilliA.CecconiD.BortesiL.PersiA.RinalducciS.ZamboniA.et al

Rev Gastroenterol Mex (Engl Ed) 2024