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Interestingly, ITE, another AhR ligand, inhibits TGF-1induced myofibroblast differentiation through an AhR-independent mechanism by blocking Smad2/3/4 nuclear translocation [116]

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54 In addition, elevated plasma nonesterified fatty acid (NEFA) levels impaired the insulin-induced increase in IRS-1-associated PI3K activity, but no defect in Akt phosphorylation was observed

Treating hypoxic mouse islet cells with the mTOR-inhibitor Torin 1 restored Tfeb protein and improved lysosomal function

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