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Some signs that require medical attention include: Frequent heartburn (more than twice a week) Regurgitation (food or stomach acid coming back up into the throat) Persistent nausea or vomiting Chest pain that does not improve with antacids Difficulty swallowing or feeling like food is stuck in the throat Unexplained weight loss that is not due to the intended effects of semaglutide Doctors can assess symptoms and determine if they are caused by semaglutide, GERD, or another condition