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The most prevalent PAH detected across all tested products was naphthalene, which ranged from 210.7 to 460.34 ng per cigarette 24

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Correspondingly, according to a survey conducted in Italy, 30% of smokers had on average 5.6 more cigarettes per day, with only 18% reporting less smoking on average, by 4.1 cigarettes per day

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7nAChRs or 9nAChRs mediated nicotine-induced cell proliferation and activation of the AKT and ERK signaling pathways [64]