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In clinical trials including MAESTRO-NASH, Resmetirom reduced hepatic fat content (as measured by MRI-PDFF), lowered liver enzyme values, improved noninvasive markers of liver fibrogenesis, and decreased liver stiffness [125,126]

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In various kidney diseases, Th17 cells are found to be abnormally active, becoming a key force driving inflammation and fibrosis (Paquissi and Abensur, 2021)