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Semaglutide: GLP-1 receptor agonist developed for type 2 diabetes Controls blood sugar, reduces appetite, and slows digestion FDA-approved for chronic weight management (Wegovy) Injected once weekly Learn more on our Semaglutide weight loss page Phentermine: Appetite suppressant in the amphetamine family Stimulates the central nervous system to reduce hunger FDA-approved since 1959 for short-term weight loss Taken orally, typically once daily Read about our Tirzepatide Medical Weight Loss Program How Do They Work Differently