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The protective effect of sulforaphane on dextran sulfate sodium-induced colitis depends on gut microbial and Nrf2-related mechanism

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Hyperglycemia alters both extracellular and intracellular metabolism, leading to effects such as glomerular hyperfiltration (4), oxidative stress (5), the accumulation of advanced glycation end products (AGEs) (6), the activation of protein kinase C (7), abnormal polyol metabolism (8), the overexpression of transforming growth factor- (TGF-) (9) and inflammation