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Consistently, independent isotopic labelling studies in human lung cancer indicated minimum glutamine utilization in vivo, with glucose and lactate being the main contributors to the TCA cycle 9,45

More recently, a low-claudin subtype has been identified

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7.1 pH) and washed with mitochondrial respiration medium MiRO5Cr (EGTA (0.5 mM), MgCl 2 (3 mM), lactobionic acid (60 mM), taurine (20 mM), potassium dihydrogen phosphate (10 mM), HEPES (20 mM), d-sucrose (110 mM), BSA fatty-acid-free (0.1%) and supplemented with creatine (20 mM) right before use) before homogenization

These compounds represent a surgical approach to endocrinology