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High doses of Vitamin C can sometimes be a concern for individuals with a history of kidney stones, as the body may convert excess Vitamin C into oxalate

If retatrutide reduces major cardiovascular events (like semaglutide did in SELECT), the heart rate increase will be viewed as a pharmacologically interesting but clinically irrelevant side effect

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The second is a marked change in glutathione compartmentation, with GSSG accumulation occurring particularly in the vacuole (Queval et al., 2011)