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Since our previous studies have demonstrated that second-hand smoke reduces the expression and activity of IDO in an allograft (12), it is likely that smoking also inhibits Treg generation in the context of transplantation, because IDO generally promotes Treg development and activation (25)

Items with Adult Signature require a recipient who is 21 years of age or older to sign at the time of delivery

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Consider tapering down if sleep disruption is severe, reducing nicotine levels gradually or seeking support for quitting may help restore rest

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