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Autoantibodies in systemic lupus erythematosus target mitochondrial RNA

Wegovy-induced nausea, vomiting, or diarrhoea can lead to fluid depletion, particularly if severe or persistent

Additionally, the loss of muscle mass has been problematic for some individuals taking this class of medication, with lean body mass accounting for up to 1540% of total weight loss

Concerns with overseas sourcing include: the difficulty of verifying manufacturing standards in another country, the potential for degradation during international shipping (particularly for temperature-sensitive peptides), the challenge of ensuring regulatory compliance across multiple jurisdictions, and the risk of counterfeit or adulterated ingredients entering the supply chain

SURMOUNT-5 is the only direct head-to-head trial among the three