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In macrophage co-culture systems, luteolin inhibits M2-like polarization, a macrophage phenotype known to promote angiogenesis, fibrosis, and lesion maintenance

Front Cell Neurosci 8:216 Alhaddad H, Gordon DM, Bell RL, Jarvis EE, Kipp ZA, Hinds TD Jr, Sari Y (2020) Chronic ethanol consumption alters glucocorticoid receptor isoform expression in stress neurocircuits and mesocorticolimbic brain regions of alcohol-preferring rats

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The GH/IGF-1 axis has well-documented effects on adipose tissue metabolism, with clinical trials showing reductions in visceral adipose tissue when IGF-1 signaling is enhanced (Berryman et al., 2013)

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