less tobacco cigarettes The difference between smoke-less tobacco, tobacco-free oral nicotine and NRT treatments – Cafosa How are Non-Combusted Cigarettes, Sometimes

This process may involve enzymes involved in nucleotide synthesis that show altered specificity due to a purine/pyrimidine nucleotide bias

By now most people know that tobacco use is a leading cause of lung cancer

This era also saw the dawn of regulation, as governments, recognizing tobaccos lucrative nature, imposed taxes and controls

4,942 1,601 6,543 6,543 +2.4 % AME 3,433 (128) 3,305 (293) 3,012 +7.6 % APMEA 1,622 102 1,724 1,724 -21.1 % Total Region 9,997 1,575 11,572 (293) 11,279 -0.8 % Net finance costs (1,819) 170 (1,649) (54) (1,703) -0.7 % Associates and joint ventures 1,681 (1,239) 442 442 -15.0 % Profit before tax 9,859 506 10,365 (347) 10,018 -1.6 % Taxation (2,094) (344) (2,438) 92 (2,346) -2.0 % Non-controlling interests (1) (125) (126) (126) -16.3 % Coupons relating to hybrid bonds net of tax (87) 29 (58) (58) +36.9 % Profit attributable to shareholders 7,677 37 7,743 (255) 7,488 -1.3 % Diluted number of shares (m) 2,199 2,199 2,199 -1.2 % Diluted earnings per share (pence) 349.1 352.1 340.5 -0.2 % 2025 at constant rates For year ended 31 December 2025 Reported Adj Items1 Adjusted Exch

The Old Bull Building opened for occupancy in 2008.