Reference clinical studies and methodological limitations In cosmetic dermatology, clinical studies on peptides are often methodologically limited : reduced sample sizes (n = 20-50), short duration (4-12 weeks), subjective measurements (self-evaluation, photography), absence of strict vehicle control
Sheil B, MacSharry J, OCallaghan L, ORiordan A, Waters A, Morgan J et al (2006) Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice
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