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Among these, lipid-based nanoparticles have attracted particular attention due to their biocompatibility, biodegradability, and adaptability for different vaccine formulations [68, 69]

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Such haptenated proteins can disrupt protein folding or function and lead to direct toxicity, or can be recognized as non-self leading to immune-mediated toxicity ( FIGURE 1 Glutathione S -transferases are important enzymes that catalyze the conjugation reaction between GSH and chemically reactive drug metabolites