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OT and AVP: The neuropeptide hormones OT and AVP belong to the same superfamily, and genetic variants in OXT , OXTR , arginine vasopressin receptor 1a ( AVPR1a ) and CD38 (lately demonstrated as essentiall for social behaviour because it mediates oxytocin secretion) have been verified to be associated with autism

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This allows it to have both localized effects (at the site of administration) and systemic effects throughout the body