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Drug families known to disrupt HPG axis signaling and/or decrease fertility by other mechanisms include 23 : Chemotherapy drugs (such as cisplatin, doxorubicin (Adriamycin, among others), 5-fluorouricil (5-FU), cyclophosphamide) 52 Psychiatric medications 23 Corticosteroids and other immune suppressants 23,69 Some blood pressure-lowering drugs including calcium channel blockers, angiotensin receptor blockers (ARBs), and angiotensin-converting enzyme inhibitors (ACEi)

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Image PMID: 24080471 GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity

Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, et al