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Similarly, ophthalmological endpoints were investigated adjusting for (1) papilledema degree, (2) pRNFL thickness, (3) GCL volume, or (3) ONSD at baseline as appropriate and in a second step also for weight loss to evaluate potential independent treatment effects of GLP-1-RAs

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On the other hand a GLP1-ANP axis has been only demonstrated in hypertensive mice, in which GLP-1R activation in the atria leads to ANP secretion and stimulation of natriuresis and vasodilation in the consequence

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