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They modulate genes crucial for lipid and glucose metabolism, thereby amplifying the insulin sensitivity of peripheral tissues

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Astrocyte glutamine synthetase: importance in hyperammonemic syndromes and potential target for therapy

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While its ~12.4% average weight loss at the highest dose might appear lower than some Semaglutide data points, a key head-to-head trial in Type 2 Diabetes (ACHIEVE-3) showed orforglipron to be superior to oral semaglutide (7mg and 14mg doses) in both A1C reduction and weight loss over 52 weeks