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This observation could be due to the limited donor size and the lack of information of non-COPD donors on sex, age and smoking status, which could potentially obscure differences between COPD and control-derived cells with respect to mitochondrial gene expression and methylation

In effect, this means that even light smoking in otherwise young healthy people can damage the arteries, compromising the ability of their bodies to cope with physical stress, such as climbing a set of stairs or running to catch a bus, says Dr

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