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Misinterpretation of Benefits : Perceived benefits based on preclinical data may not translate to humans, which can lead to inappropriate use without proven outcomes

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Congestive heart failure Congestive heart failure (deterioration of the hearts ability to pump blood) is associated with a high risk of sudden cardiac death from arrhythmia (Nessler 2007

Scientific data suggests that the FOXO family of proteins may act downstream of insulin signaling to regulate cellular growth, metabolism, differentiation, and oxidative stress

Conversely, dysregulation of lipid metabolism triggers the aggregation of -syn, forming a vicious cycle (138)