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The retrospective design, reliance on self-reported data, lack of information on dietary factors, unmeasured heavy metal exposure, and unaccounted variability in E-cigarette devices all limit causal conclusions and generalizability

- Cigarettes are as addictive as drugs such as heroin or cocaine

We estimate that smoking causes at least half of the remaining 17 percent through diseases that have not previously been recognized as being caused by cigarette smoking, said Neal Freedman, Ph.D., a co-investigator on the study from NCIs Division of Cancer Epidemiology and Genetics

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