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Preclinical studies and clinical trials suggest that antioxidants, such as small thiol molecules (N-acetyl-L-cysteine and carbocysteine), antioxidant enzymes (glutathione peroxidases), activators of Nrf2-regulated antioxidant defense system (sulforaphane), and vitamins, for example, C, E, and D, enhance the endogenous antioxidant system and reduce oxidative stress

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In patients with cancer, diabetes or neurodegeneration, NADs and glutathiones showed disease-dependent redox fingerprints

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Nicolay JP, Gatz S, Lang F, Lang UE